Kelley, Yun (2012) Proteomics large-scale study of proteins. White Word Publications, Delhi, India. ISBN 9788132343219
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Abstract
Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term "proteomics" was first coined in 1997 to make an analogy with genomics, the study of the genes. The word "proteome" is a blend of "protein" and "genome", and was coined by Marc Wilkins in 1994 while working on the concept as a PhD student. The proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by a cell or organism undergoing an organism or system. This will vary with time and distinct requirements, or stresses, that a Complexity of the problem. After genomics, proteomics is considered the next step in the study of biological systems. It is much more complicated than genomics mostly because while an organism's genome is more or less constant, the proteome changes from cell to cell and from time to time. This is because distinct genes are expressed in distinct cell types. This means that even the basic set of proteins which are produced in a cell needs to be determined. In the past this was done by mRNA analysis, but this was found not to correlate with protein content. It is now known that mRNA is not always translated into protein, and the amount of protein produced for a given amount of mRNA depends on the gene it is transcribed from and on the current physiological state of the cell. Proteomics confirms the presence of the protein and provides a direct measure of the quantity present.
| Item Type: | Book |
|---|---|
| Subjects: | Q Science > QP Physiology |
| Divisions: | Electronic Books |
| Depositing User: | Esam @ Hisham Muhammad |
| Date Deposited: | 12 Feb 2023 06:46 |
| Last Modified: | 12 Feb 2023 06:46 |
| URI: | http://odlsystem2.utm.my/id/eprint/3968 |
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