Ison, Alfredo and Lawton, Colin (2012) Cancer and AIDS research and treatments. College Publishing House, Delhi, India. ISBN 9788132313786
Preview |
Text
Cancerandaidsresearch_AlfredoColin.pdf - Published Version Download (2MB) | Preview |
Abstract
Experimental cancer treatments are medical therapies intended or claimed to treat cancer by improving on, supplementing or replacing conventional methods (surgery, chemotherapy, radiation, and immunotherapy). The entries listed below vary between theoretical therapies to unproven controversial therapies. Many of these treatments are alleged to only help against specific forms of cancer. It is not a list of treatments widely available at hospitals. Bacterial treatments Chemotherapeutic drugs have a hard time penetrating tumors to kill them at their core because these cells may lack a good blood supply. Researchers have been using anaerobic bacteria, such as Clostridium novyi, to consume the interior of oxygen-poor tumors. These should then die when they come in contact with the tumor's oxygenated sides, meaning they would be harmless to the rest of the body. A major problem has been that bacteria don't consume all parts of the malignant tissue. However combining the therapy with chemotherapy treatments can help to solve this problem. Another strategy is to use anaerobic bacteria that have been transformed with an enzyme that can convert a non-toxic prodrug into a toxic drug. With the proliferation of the bacteria in the necrotic and hypoxic areas of the tumor the enzyme is expressed solely in the tumor. Thus a systemically applied prodrug is metabolized to the toxic drug only in the tumor. This has been demonstrated to be effective with the non pathogenic anaerobe Clostridium sporogenes.
| Item Type: | Book |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Electronic Books |
| Depositing User: | Esam @ Hisham Muhammad |
| Date Deposited: | 02 Jan 2023 00:56 |
| Last Modified: | 02 Jan 2023 00:56 |
| URI: | http://odlsystem2.utm.my/id/eprint/3747 |
Actions (login required)
 |
View Item |